![]() We obtained an understanding of different regulatory pathways in breast cancer and new insights on how these signalling pathways are activated. This method can be generalized to other drugs and longer time courses to better understand how resistance to drugs develops in cancer cells over time.īreast cancer represents a major public health issue, affecting one in eight women in the Western world. Approximately 25% of human breast cancer cases are HER2-positive, due to overexpression of the HER2 protein or amplification of the HER2 gene, or due to activating mutations that increase HER2 activity. HER2-positive tumours are associated with poor prognosis. HER2 is a 185 kDa protein that belongs to the family of tyrosine kinase epidermal growth factor receptors, and is also known as Neu or ErbB2. HER2 has no known ligand and is activated by dimerization or by incorporation into heterodimers with its related family members HER1, HER3 or HER4. ![]() Increased membrane receptor concentration of HER2 in HER2-overexpressing cells can also activate HER2 by ligand-independent homo-dimerization, leading to activation of the HER2 signalling pathway. GRAPHPAD PRISM 7.0A MACOSX 29.1 MB FULL SERIES.
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